People

Derek Dee
Assistant Professor

I am a food scientist and biophysicist, having focused on the folding mechanisms of aspartic proteases, the misfolding and aggreagation of prion protein at the single molecule level, and the conversion of food related proteins into nanofibrils.

Office FNH 240
Office phone 604-822-4489
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Katarzyna ‘Kasia’ Skrzypczak
Ph.D., (Lublin, Poland).

Dekaban Foundation and LFS

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Drew Sanders
Ph.D. candidate, co-supervised with prof. Rickey Yada.

I am using optical tweezers to investigate pepsin and pepsinogen folding at the single molecule level. These proteins are an excellent model for studying protein (kinetic) stability, which remains poorly understood, and characterizing how evolution sculpts protein folding energy landscapes. Better understanding these basic properties may have utility in engineering novel, industrially-relevant enzymes for stable catalysis under a wider range of conditions and in targeting pepsin-like proteases involved in several diseases.

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Leslie Huynh
Master’s student, co-supervised with prof. Rickey Yada.

I joined the Dee Lab in September 2023 after completing my Bachelor’s degree in Food Science at the University of Guelph. My research focuses on recombinant expression and characterization of pepsin-like proteases from cold-adapted yeast. We want to better understand how extremophilic enzymes have adapted to fold and function in harsh environments. Besides protein engineering, this research can be useful in applications which require lower temperatures, such as cold-wash detergents, leather manufacturing and cold-ripening of cheeses.

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Aicha Asma Houfani
Ph.D. Microbiology, Postdoctoral Research Fellow.

I joined Derek’s lab to use advanced proteomics tools to characterize seed-storage proteins from legumes, focusing on pea proteins initially, to understand how protein structural changes contribute to quality attributes of pea protein used in food.

With a microbiology background from bachelor’s to PhD, I’ve spent the past few years as a postdoc at UBC, diving into three major research projects. Along the way, I’ve gained expertise in mass spectrometry-based proteomics and protein biochemistry through collaborations with local industries via Mitacs programs and BC Cancer at Leonard Foster Lab’s to develop and apply (phospho)proteomics for studying the mechanism of action of a small molecule drug and combination therapeutics, as well as developing proteomics for protein corona characterization with lipid nanoparticles. More recently, I’ve been working with the NRC and Derek Dee’s Lab on a cutting-edge sustainable protein production project focused on legume proteomics. Wrapping up my postdoc, I’m shifting back to microbiology to explore plant-specific inserts from Solanum tuberosum and their antifungal properties, working with Dr. Lennie Cheung and Prof. Rickey Yada. On the side, I will also be assisting with recombinant protein expression experiments in Dee Lab.

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Daniel Foster
Ph.D. Physics. (Focus areas: biophysics and optics)

I joined Derek’s lab in the fall of 2021, to help with the single molecule biophysics work using optical tweezers for force spectroscopy. During my graduate studies at the University of Alberta, I was part of a team who built three optical tweezers instruments in Michael Woodside’s lab. Here at UBC we have the commercial Lumicks’ C-trap with which we explore protein folding.

My graduate research focused on both optical tweezers construction (optics, alignments, programming, CAD) and advancing measurement capabilities, while studying the folding of nucleic acids, both the DNA hairpin model systems, and RNA regulatory elements such as riboswitches and frame shifting pseudoknots. My post doctoral research involved the prototyping of microfluidic devices (from the cleanroom to the wet bench) and the (stop/slit) flow lithography of functional hydrogels (fluophores and functional proteins) in Dae Kun Hwang’s lab in Toronto.

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Rachel Rosenberg (UBC undergraduate NSERC USRA)

I am currently doing my undergraduate degree in food science at UBC. At the Dee lab this summer I will be working on and gaining valuable skills pertaining to recombinant protein expression and purification. I am passionate about creating sustainable food systems via precision fermentation/recombinant protein expression to create alternative protein sources.

Hrishika Dekate (MITACS Globalink intern)

My project focuses on the detailed study of protein dynamics using single-molecule force spectroscopy with optical tweezers, overcoming the limitations of ensemble averaging in bulk samples. By examining single molecules, we aim to uncover critical features such as folding intermediates and misfolded states, which are vital for understanding neurodegenerative diseases.
I am pursuing my undergraduate degree as a chemistry major & biology minor at IISER Kolkata (India); during my internship in Dee Lab, I aspire to learn new skills involving the expression and purification of proteins along with ThT kinetic studies.

Outside of the lab, I enjoy cooking, reading and travelling.